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Molecular and Clinical Assessment in the Treatment of AIDS Kaposi Sarcoma with Valproic Acid

Maryjo Lechowicz, Dirk P. Dittmer, Jeannette Y. Lee, Susan E. Krown, William Wachsman, David Aboulafia, Bruce J. Dezube, Lee Ratner, Jonathan Said and Richard F. Ambinder
Clinical Infectious Diseases
Vol. 49, No. 12 (15 December 2009), pp. 1946-1949
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/27799477
Page Count: 4
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Molecular and Clinical Assessment in the Treatment of AIDS Kaposi Sarcoma with Valproic Acid
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Abstract

The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy.

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