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Neurofibrillary Tangles of Alzheimer Disease Share Antigenic Determinants with the Axonal Microtubule-Associated Protein Tau (τ )
John G. Wood, Suzanne S. Mirra, Nancy J. Pollock and Lester I. Binder
Proceedings of the National Academy of Sciences of the United States of America
Vol. 83, No. 11 (Jun. 1, 1986), pp. 4040-4043
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/27824
Page Count: 4
You can always find the topics here!Topics: Antibodies, Epitopes, Hippocampus, Neurofibrillary tangles, Axons, Microtubules, Dendrites, Monoclonal antibodies, Product labeling, Neurons
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The relationship of the neurofibrillary tangle, found in Alzheimer disease and aged brains, to normal or abnormal cytoskeletal proteins remains elusive. Although immunohistochemical studies have yielded disparate results, most antigenic determinants localized to neurofibrillary tangles are cytoskeletal constituents normally present in neuronal perikarya or dendrites. We report light and electron microscopic immunolabeling of neurofibrillary tangles by a monoclonal antibody to the microtubule-associated protein tau (τ ). Dephosphorylation of tissue slices not only increased the number of τ -positive tangles but also produced marked positive immunoreactivity of neuritic plaques. The localization of τ , an axonal protein, to neurofibrillary tangles in the perikaryon in particular suggests that abnormal synthesis, modification, or aggregation of τ may induce aberrant cytoskeletal-cell organelle interactions, subsequent interference with axonal flow, and resultant tangle formation.
Proceedings of the National Academy of Sciences of the United States of America © 1986 National Academy of Sciences