Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Patients with IgA Nephropathy Have Circulating Anti-Basement Membrane Antibodies Reacting with Structures Common to Collagen I, II, and IV

Bo Cederholm, Jörgen Wieslander, Per Bygren and Dick Heinegård
Proceedings of the National Academy of Sciences of the United States of America
Vol. 83, No. 16 (Aug. 15, 1986), pp. 6151-6155
Stable URL: http://www.jstor.org/stable/28114
Page Count: 5
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Patients with IgA Nephropathy Have Circulating Anti-Basement Membrane Antibodies Reacting with Structures Common to Collagen I, II, and IV
Preview not available

Abstract

It has recently been shown that patients with IgA nephropathy have circulating IgA antibodies against extracts of human glomerular basement membrane. The present study extends those observations and demonstrates by using ELISA and immunoblotting techniques that patients with IgA nephropathy have circulating IgA antibodies against collagen IV α chains. The antigenicity of the α chains could be destroyed by digestion with collagenase, which indicates that the antigenic site(s) is located on the triple helical part of collagen IV. Furthermore, it was shown by inhibition tests that the IgA antibodies are directed against epitopes also present in collagen I and II isolated after pepsin digestion.

Page Thumbnails

  • Thumbnail: Page 
6151
    6151
  • Thumbnail: Page 
6152
    6152
  • Thumbnail: Page 
6153
    6153
  • Thumbnail: Page 
6154
    6154
  • Thumbnail: Page 
6155
    6155