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Similarity of Human Mitochondrial Transcription Factor 1 to High Mobility Group Proteins

Melissa A. Parisi and David A. Clayton
Science
New Series, Vol. 252, No. 5008 (May 17, 1991), pp. 965-969
Stable URL: http://www.jstor.org/stable/2875357
Page Count: 5
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Similarity of Human Mitochondrial Transcription Factor 1 to High Mobility Group Proteins
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Abstract

Human mitochondrial transcription factor 1 (mtTF1) has been sequenced and is a nucleus-encoded DNA binding protein of 204 amino acids (24,400 daltons). Expression of human mtTF1 in bacteria yields a protein with correct physical properties and the ability to activate mitochondrial DNA promoters. Analysis of the protein's sequence reveals no similarities to any other DNA binding proteins except for the existence of two domains that are characteristic of high mobility group (HMG) proteins. Human mtTF1 is most closely related to a DNA binding HMG-box region in hUBF, a human protein known to be important for transcription by RNA polymerase I.

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