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Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

Yufang Shi, Jacqueline M. Glynn, Lawrence J. Guilbert, Thomas G. Cotter, Reid P. Bissonnette and Douglas R. Green
Science
New Series, Vol. 257, No. 5067 (Jul. 10, 1992), pp. 212-214
Stable URL: http://www.jstor.org/stable/2877524
Page Count: 3
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Abstract

Immature T cells and some T cell hybridomas undergo apoptotic cell death when activated through the T cell receptor complex, a phenomenon that is probably related to antigen induced negative selection of developing T cells. This activation-induced apoptosis depends on active protein and RNA synthesis in the dying cells, although none of the genes required for this process have previously been identified. Antisense oligonucleotides corresponding to c-myc block the constitutive expression of c-Myc protein in T cell hybridomas and interfere with all aspects of activation-induced apoptosis without affecting lymphokine production in these cells. These data indicate that c-myc expression is a necessary component of activation-induced apoptosis.

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