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Planar Induction of Anteroposterior Pattern in the Developing Central Nervous System of Xenopus laevis
Tabitha Doniach, Carey R. Phillips and John C. Gerhart
New Series, Vol. 257, No. 5069 (Jul. 24, 1992), pp. 542-545
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/2877770
Page Count: 4
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It has long been thought that anteroposterior (A-P) pattern in the vertebrate central nervous system is induced in the embryo's dorsal ectoderm exclusively by signals passing vertically from underlying, patterned dorsal mesoderm. Explants from early gastrulae of the frog Xenopus laevis were prepared in which vertical contact between dorsal ectoderm and mesoderm was prevented but planar contact was maintained. In these, four position-specific neural markers (engrailed-2, Krox-20, XIHbox 1, and XIHbox 6) were expressed in the ectoderm in the same A-P order as in the embryo. Thus, planar signals alone, following a path available in the normal embryo, can induce A-P neural pattern.
Science © 1992 American Association for the Advancement of Science