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Tetraplex Formation of a Guanine-Containing Nonameric DNA Fragment
Renzhe Jin, Kenneth J. Breslauer, Roger A. Jones and Barbara L. Gaffney
New Series, Vol. 250, No. 4980 (Oct. 26, 1990), pp. 543-546
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/2878448
Page Count: 4
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A combination of spectroscopic and calorimetric techniques has been used to characterize the structures formed by a family of short, guanine-containing DNA single strands of the form d[GGTTXTTGG], X = A, C, G, T. In 1 molar NaCl at low temperatures, these molecules do not behave like single strands, but rather exhibit properties consistent with tetraplex formation. The standard state enthalpies, entropies, and free energies for formation of each tetraplex have been measured, as have preliminary nuclear magnetic resonance (NMR) spectra. In 1 molar KCl, the melting behavior of the structure or structures is more complex than in 1 molar NaCl. This observation may be related to the recently proposed "sodium-potassium switch."
Science © 1990 American Association for the Advancement of Science