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Genetic Mapping of a Locus Predisposing to Human Colorectal Cancer
Päivi Peltomäki, Lauri A. Aaltonen, Pertti Sistonen, Lea Pylkkänen, Jukka-Pekka Mecklin, Heikki Järvinen, Jane S. Green, Jeremy R. Jass, James L. Weber, Fredrick S. Leach, Gloria M. Petersen, Stanley R. Hamilton, Albert de la Chapelle and Bert Vogelstein
New Series, Vol. 260, No. 5109 (May 7, 1993), pp. 810-812
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/2881171
Page Count: 3
You can always find the topics here!Topics: Hereditary nonpolyposis colorectal neoplasms, Colorectal cancer, Lod score, Cancer, Microsatellite repeats, Chromosomes, Medical research, Tumors, Genetic loci, Genetic diseases
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Genetic linkage analysis was used to determine whether a specific chromosomal locus could be implicated in families with a history of early onset cancer but with no other unique features. Close linkage of disease to anonymous microsatellite markers on chromosome 2 was demonstrated in two large kindreds. The pairwise lod scores for linkage to marker D2S123 in these kindreds were 6.39 and 1.45 at zero recombination, and multipoint linkage with flanking markers resulted in lod scores of 6.47 and 6.01. These results prove the existence of a genetically determined predisposition to colorectal cancer that has important ramifications for understanding and preventing this disease.
Science © 1993 American Association for the Advancement of Science