Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

Hilmar Bading, David D. Ginty and Michael E. Greenberg
Science
New Series, Vol. 260, No. 5105 (Apr. 9, 1993), pp. 181-186
Stable URL: http://www.jstor.org/stable/2881300
Page Count: 6
  • More info
  • Cite this Item
Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways
Preview not available

Abstract

Calcium ions (Ca$^{2+}$) act as an intracellular second messenger and can enter neurons through various ion channels. Influx of Ca$^{2+}$ through distinct types of Ca$^{2+}$ channels may differentially activate biochemical processes. N-Methyl-D-aspartate (NMDA) receptors and L-type Ca$^{2+}$ channels, two major sites of Ca$^{2+}$ entry into hippocampal neurons, were found to transmit signals to the nucleus and regulated gene transcription through two distinct Ca$^{2+}$ signaling pathways. Activation of the multifunctional Ca$^{2+}$-calmodulin-dependent protein kinase (CaM kinase) was evoked by stimulation of either NMDA receptors or L-type Ca$^{2+}$ channels; however, activation of CaM kinase appeared to be critical only for propagating the L-type Ca$^{2+}$ channel signal to the nucleus. Also, the NMDA receptor and L-type Ca$^{2+}$ channel pathways activated transcription by means of different cis-acting regulatory elements in the c-fos promoter. These results indicate that Ca$^{2+}$, depending on its mode of entry into neurons, can activate two distinct signaling pathways. Differential signal processing may provide a mechanism by which Ca$^{2+}$ controls diverse cellular functions.

Page Thumbnails

  • Thumbnail: Page 
181
    181
  • Thumbnail: Page 
182
    182
  • Thumbnail: Page 
183
    183
  • Thumbnail: Page 
184
    184
  • Thumbnail: Page 
185
    185
  • Thumbnail: Page 
186
    186