If you need an accessible version of this item please contact JSTOR User Support

A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation

Dean H. Hamer, Stella Hu, Victoria L. Magnuson, Nan Hu and Angela M. L. Pattatucci
Science
New Series, Vol. 261, No. 5119 (Jul. 16, 1993), pp. 321-327
Stable URL: http://www.jstor.org/stable/2881563
Page Count: 7
  • Download PDF
  • Cite this Item

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If you need an accessible version of this item please contact JSTOR User Support
A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation
Preview not available

Abstract

The role of genetics in male sexual orientation was investigated by pedigree and linkage analyses on 114 families of homosexual men. Increased rates of same-sex orientation were found in the maternal uncles and male cousins of these subjects, but not in their fathers or paternal relatives, suggesting the possibility of sex-linked transmission in a portion of the population. DNA linkage analysis of a selected group of 40 families in which there were two gay brothers and no indication of nonmaternal transmission revealed a correlation between homosexual orientation and the inheritance of polymorphic markers on the X chromosome in approximately 64 percent of the sib-pairs tested. The linkage to markers on Xq28, the subtelomeric region of the long arm of the sex chromosome, had a multipoint lod score of 4.0 (P = 10$^{-5}$), indicating a statistical confidence level of more than 99 percent that at least one subtype of male sexual orientation is genetically influenced.

Page Thumbnails

  • Thumbnail: Page 
321
    321
  • Thumbnail: Page 
322
    322
  • Thumbnail: Page 
323
    323
  • Thumbnail: Page 
324
    324
  • Thumbnail: Page 
325
    325
  • Thumbnail: Page 
326
    326
  • Thumbnail: Page 
327
    327