Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Mesodermal Patterning by a Gradient of the Vertebrate Homeobox Gene goosecoid

Christof Niehrs, Herbert Steinbeisser and Eddy M. De Robertis
Science
New Series, Vol. 263, No. 5148 (Feb. 11, 1994), pp. 817-820
Stable URL: http://www.jstor.org/stable/2882929
Page Count: 4
  • More info
  • Cite this Item
Mesodermal Patterning by a Gradient of the Vertebrate Homeobox Gene goosecoid
Preview not available

Abstract

Amphibian mesoderm arises from the marginal zone of the early gastrula and generates various tissues such as notochord, muscle, kidney, and blood. Small changes (twofold) in the amount of microinjected messenger RNA encoding the goosecoid (gsc) homeodomain protein resulted in marked changes in the differentiation of mesoderm in Xenopus laevis. At least three thresholds were observed, which were sufficient to specify four mesodermal cell states. Endogenous gsc messenger RNA was expressed in the marginal zone in a graded fashion that is congruent with a role for this gene in dorso-ventral patterning of mesoderm at the early gastrula stage.

Page Thumbnails

  • Thumbnail: Page 
817
    817
  • Thumbnail: Page 
818
    818
  • Thumbnail: Page 
819
    819
  • Thumbnail: Page 
820
    820