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Mesodermal Patterning by a Gradient of the Vertebrate Homeobox Gene goosecoid
Christof Niehrs, Herbert Steinbeisser and Eddy M. De Robertis
New Series, Vol. 263, No. 5148 (Feb. 11, 1994), pp. 817-820
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/2882929
Page Count: 4
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Amphibian mesoderm arises from the marginal zone of the early gastrula and generates various tissues such as notochord, muscle, kidney, and blood. Small changes (twofold) in the amount of microinjected messenger RNA encoding the goosecoid (gsc) homeodomain protein resulted in marked changes in the differentiation of mesoderm in Xenopus laevis. At least three thresholds were observed, which were sufficient to specify four mesodermal cell states. Endogenous gsc messenger RNA was expressed in the marginal zone in a graded fashion that is congruent with a role for this gene in dorso-ventral patterning of mesoderm at the early gastrula stage.
Science © 1994 American Association for the Advancement of Science