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Maspin, a Serpin with Tumor-Suppressing Activity in Human Mammary Epithelial Cells

Zhiqiang Zou, Anthony Anisowicz, Mary J. C. Hendrix, Ann Thor, Mark Neveu, Shijie Sheng, Kristina Rafidi, Elisabeth Seftor and Ruth Sager
Science
New Series, Vol. 263, No. 5146 (Jan. 28, 1994), pp. 526-529
Stable URL: http://www.jstor.org/stable/2883035
Page Count: 4
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Abstract

A gene encoding a protein related to the serpin family of protease inhibitors was identified as a candidate tumor suppressor gene that may play a role in human breast cancer. The gene product, called maspin, is expressed in normal mammary epithelial cells but not in most mammary carcinoma cell lines. Transfection of MDA-MB-435 mammary carcinoma cells with the maspin gene did not alter the cells' growth properties in vitro, but reduced the cells' ability to induce tumors and metastasize in nude mice and to invade through a basement membrane matrix in vitro. Analysis of human breast cancer specimens revealed that loss of maspin expression occurred most frequently in advanced cancers. These results support the hypothesis that maspin functions as a tumor suppressor.

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