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Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing

Hilda Lomeli, Johannes Mosbacher, Thorsten Melcher, Thomas Höger, Jörg R. P. Geiger, Thomas Kuner, Hannah Monyer, Miyoko Higuchi, Alfred Bach and Peter H. Seeburg
Science
New Series, Vol. 266, No. 5191 (Dec. 9, 1994), pp. 1709-1713
Stable URL: http://www.jstor.org/stable/2885243
Page Count: 5
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Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing
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Abstract

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central nervous system. Site-selective nuclear RNA editing controls the calcium permeability of these channels, and RNA editing at a second site is shown here to affect the kinetic aspects of these channels in rat brain. In three of the four AMPA receptor subunits (GluR-B, -C, and -D), intronic elements determine a codon switch (AGA, arginine, to GGA, glycine) in the primary transcripts in a position termed the R/G site, which immediately precedes the alternatively spliced modules "flip" and "flop." The extent of editing at this site progresses with brain development in a manner specific for subunit and splice form, and edited channels possess faster recovery rates from desensitization.

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