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Erythrocyte P Antigen: Cellular Receptor for B19 Parvovirus
Kevin E. Brown, Stacie M. Anderson and Neal S. Young
New Series, Vol. 262, No. 5130, Genome Issue (Oct. 1, 1993), pp. 114-117
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/2885679
Page Count: 4
You can always find the topics here!Topics: Globosides, Antigens, Parvovirus, Viruses, Lipids, Capsid, Phenotypes, Monoclonal antibodies, Erythrocytes, Hemagglutination
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The pathogenic human parvovirus B19 replicates only in erythroid progenitor cells. This virus was shown to bind to blood-group P antigen, as measured by hemagglutination. Erythrocytes lacking P antigen were not agglutinated with B19. Purified P antigen (globoside) blocked the binding of the virus to erythroid cells and the infectivity of the virus in a hematopoietic colony assay. Target cells were protected from infection by preincubation with monoclonal antibody to globoside. Knowledge of a parvovirus receptor has implications for understanding the pathogenesis of parvovirus infections and for the use of parveviruses in gene therapy.
Science © 1993 American Association for the Advancement of Science