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A Role for Exonuclease I from S. pombe in Mutation Avoidance and Mismatch Correction

Philippe Szankasi and Gerald R. Smith
Science
New Series, Vol. 267, No. 5201 (Feb. 24, 1995), pp. 1166-1169
Stable URL: http://www.jstor.org/stable/2886091
Page Count: 4
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A Role for Exonuclease I from S. pombe in Mutation Avoidance and Mismatch Correction
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Abstract

Exonuclease I (Exo I) from Schizosaccharomyces pombe, a 5′ → 3′ double-stranded DNA exonuclease, is induced during meiotic prophase I. The exo1 gene is a member of a family of related DNA repair genes, including RAD2/rad13/xpgc and YKL510/rad2, conserved from yeast to humans. An exo1 mutant displays a mutator phenotype and alters activity of the ade6-M387 marker effect. These results suggest that Exo I acts in a pathway that corrects mismatched base pairs.

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