You are not currently logged in.
Access your personal account or get JSTOR access through your library or other institution:
KAl1, a Metastasis Suppressor Gene for Prostate Cancer on Human Chromosome 11p 11.2
Jin-Tang Dong, Pattie W. Lamb, Carrie W. Rinker-Schaeffer, Jasminka Vukanovic, Tomohiko Ichikawa, John T. Isaacs and J. Carl Barrett
New Series, Vol. 268, No. 5212 (May 12, 1995), pp. 884-886
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/2887974
Page Count: 3
Preview not available
A gene from human chromosome 11p11.2 was isolated and was shown to suppress metastasis when introduced into rat AT6.1 prostate cancer cells. Expression of this gene, designated KAI1, was reduced in human cell lines derived from metastatic prostate tumors. KAI1 specifies a protein of 267 amino acids, with four hydrophobic and presumably transmembrane domains and one large extracellular hydrophilic domain with three potential N-glycosylation sites. KAI1 is evolutionarily conserved, is expressed in many human tissues, and encodes a member of a structurally distinct family of leukocyte surface glycoproteins. Decreased expression of this gene may be involved in the malignant progression of prostate and other cancers.
Science © 1995 American Association for the Advancement of Science