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Origin of Bilaterian Body Plans: Evolution of Developmental Regulatory Mechanisms

Eric H. Davidson, Kevin J. Peterson and R. Andrew Cameron
Science
New Series, Vol. 270, No. 5240 (Nov. 24, 1995), pp. 1319-1325
Stable URL: http://www.jstor.org/stable/2888672
Page Count: 7
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Origin of Bilaterian Body Plans: Evolution of Developmental Regulatory Mechanisms
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Abstract

An argument is proposed to explain the origin of large metazoans, based on the regulatory processes that underlie the morphogenetic organization of pattern in modern animals. Genetic regulatory systems similar to those used in modern, indirectly developing marine invertebrates are considered to indicate the Precambrian regulatory platform on which were erected innovations that underlie the development of macroscopic body plans. Those systems are genetic regulatory programs that produce groups of unspecified "set-aside cells" and hierarchical regulatory programs that initially define regions of morphogenetic space in terms of domains of transcription factor expression. These ideas affect interpretation of the development of arthropods and chordates as well as interpretation of the role of the genes of the homeotic complex in embryogenesis.

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