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Targeting of Motor Proteins
Richard B. Vallee and Michael P. Sheetz
New Series, Vol. 271, No. 5255 (Mar. 15, 1996), pp. 1539-1544
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/2890716
Page Count: 6
You can always find the topics here!Topics: Microtubules, Organelles, Motors, Kinetochores, Molecules, Cell membranes, Binding sites, Chromosomes, Antibodies, Skeleton
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Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules. How these proteins are targeted to the appropriate organellar sites within the cell, however, has remained a mystery. Recent work has begun to define the targeting mechanism for two well-studied motor proteins, kinesin and cytoplasmic dynein.
Science © 1996 American Association for the Advancement of Science