Access

You are not currently logged in.

Access JSTOR through your library or other institution:

login

Log in through your institution.

Journal Article

Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search

Jeffrey R. Smith, Diha Freije, John D. Carpten, Henrik Grönberg, Jianfeng Xu, Sarah D. Isaacs, Michael J. Brownstein, G. Steven Bova, Hong Guo, Piroska Bujnovszky, Deborah R. Nusskern, Jan-Erik Damber, Anders Bergh, Monika Emanuelsson, Olli P. Kallioniemi, Jennifer Walker-Daniels, Joan E. Bailey-Wilson, Terri H. Beaty, Deborah A. Meyers, Patrick C. Walsh, Francis S. Collins, Jeffrey M. Trent and William B. Isaacs
Science
New Series, Vol. 274, No. 5291 (Nov. 22, 1996), pp. 1371-1374
Stable URL: http://www.jstor.org/stable/2892059
Page Count: 4
Were these topics helpful?
See something inaccurate? Let us know!

Select the topics that are inaccurate.

Cancel
  • More info
  • Add to My Lists
  • Cite this Item
Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search
Preview not available

Abstract

Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.

Page Thumbnails

  • Thumbnail: Page 
1371
    1371
  • Thumbnail: Page 
1372
    1372
  • Thumbnail: Page 
1373
    1373
  • Thumbnail: Page 
1374
    1374