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Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search
Jeffrey R. Smith, Diha Freije, John D. Carpten, Henrik Grönberg, Jianfeng Xu, Sarah D. Isaacs, Michael J. Brownstein, G. Steven Bova, Hong Guo, Piroska Bujnovszky, Deborah R. Nusskern, Jan-Erik Damber, Anders Bergh, Monika Emanuelsson, Olli P. Kallioniemi, Jennifer Walker-Daniels, Joan E. Bailey-Wilson, Terri H. Beaty, Deborah A. Meyers, Patrick C. Walsh, Francis S. Collins, Jeffrey M. Trent and William B. Isaacs
New Series, Vol. 274, No. 5291 (Nov. 22, 1996), pp. 1371-1374
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/2892059
Page Count: 4
You can always find the topics here!Topics: Prostate cancer, Chromosomes, Lod score, Alleles, Genetic loci, Age of onset, Z score, Family members, Genetic inheritance, Genotypes
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Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.
Science © 1996 American Association for the Advancement of Science