Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Reciprocal Inhibitory Connections and Network Synchrony in the Mammalian Thalamus

Molly M. Huntsman, Darrell M. Porcello, Gregg E. Homanics, Timothy M. DeLorey and John R. Huguenard
Science
New Series, Vol. 283, No. 5401 (Jan. 22, 1999), pp. 541-543
Stable URL: http://www.jstor.org/stable/2896965
Page Count: 3
  • More info
  • Cite this Item
Reciprocal Inhibitory Connections and Network Synchrony in the Mammalian Thalamus
Preview not available

Abstract

Neuronal rhythmic activities within thalamocortical circuits range from partially synchronous oscillations during normal sleep to hypersynchrony associated with absence epilepsy. It has been proposed that recurrent inhibition within the thalamic reticular nucleus serves to reduce synchrony and thus prevents seizures. Inhibition and synchrony in slices from mice devoid of the γ-aminobutyric acid type-A (GABA$_A$) receptor $\beta_3$ subunit were examined, because in rodent thalamus, $\beta_3$ is largely restricted to reticular nucleus. In $\beta_3$ knockout mice, GABA$_A$-mediated inhibition was nearly abolished in reticular nucleus, but was unaffected in relay cells. In addition, oscillatory synchrony was dramatically intensified. Thus, recurrent inhibitory connections within reticular nucleus act as "desynchronizers."

Page Thumbnails

  • Thumbnail: Page 
541
    541
  • Thumbnail: Page 
542
    542
  • Thumbnail: Page 
543
    543