You are not currently logged in.
Access JSTOR through your library or other institution:
Reciprocal Inhibitory Connections and Network Synchrony in the Mammalian Thalamus
Molly M. Huntsman, Darrell M. Porcello, Gregg E. Homanics, Timothy M. DeLorey and John R. Huguenard
New Series, Vol. 283, No. 5401 (Jan. 22, 1999), pp. 541-543
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/2896965
Page Count: 3
You can always find the topics here!Topics: Neurons, Knockout mice, Thalamus, Receptors, Neuroscience, Sleep, Rodents, Electrodes, Pipettes
Were these topics helpful?See something inaccurate? Let us know!
Select the topics that are inaccurate.
Preview not available
Neuronal rhythmic activities within thalamocortical circuits range from partially synchronous oscillations during normal sleep to hypersynchrony associated with absence epilepsy. It has been proposed that recurrent inhibition within the thalamic reticular nucleus serves to reduce synchrony and thus prevents seizures. Inhibition and synchrony in slices from mice devoid of the γ-aminobutyric acid type-A (GABA$_A$) receptor $\beta_3$ subunit were examined, because in rodent thalamus, $\beta_3$ is largely restricted to reticular nucleus. In $\beta_3$ knockout mice, GABA$_A$-mediated inhibition was nearly abolished in reticular nucleus, but was unaffected in relay cells. In addition, oscillatory synchrony was dramatically intensified. Thus, recurrent inhibitory connections within reticular nucleus act as "desynchronizers."
Science © 1999 American Association for the Advancement of Science