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AP-2 Recruitment to Synaptotagmin Stimulated by Tyrosine-Based Endocytic Motifs

Volker Haucke and Pietro De Camilli
Science
New Series, Vol. 285, No. 5431 (Aug. 20, 1999), pp. 1268-1271
Stable URL: http://www.jstor.org/stable/2897891
Page Count: 4
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Abstract

Clathrin-mediated endocytosis is initiated by the recruitment of the clathrin adaptor protein AP-2 to the plasma membrane where the membrane protein synaptotagmin is thought to act as a docking site. AP-2 also interacts with endocytic motifs present in other cargo proteins. Peptides with a tyrosine-based endocytic motif stimulated binding of AP-2 to synaptotagmin and enhanced AP-2 recruitment to the plasma membrane of neuronal and non-neuronal cells. This suggests a mechanism by which nucleation of clathrin-coated pits is stimulated by the loading of cargo proteins.

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