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Positive Selection of Natural Autoreactive B Cells

Kyoko Hayakawa, Masanao Asano, Susan A. Shinton, Ming Gui, David Allman, Colin L. Stewart, Jack Silver and Richard R. Hardy
Science
New Series, Vol. 285, No. 5424 (Jul. 2, 1999), pp. 113-116
Stable URL: http://www.jstor.org/stable/2898269
Page Count: 4
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Positive Selection of Natural Autoreactive B Cells
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Abstract

Lymphocyte development is critically influenced by self-antigens. T cells are subject to both positive and negative selection, depending on their degree of self-reactivity. Although B cells are subject to negative selection, it has been difficult to test whether self-antigen plays any positive role in B cell development. A murine model system of naturally generated autoreactive B cells with a germ line gene-encoded specificity for the Thy-1 (CD90) glycoprotein was developed, in which the presence of self-antigen promotes B cell accumulation and serum autoantibody secretion. Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity.

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