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Positive Selection of Natural Autoreactive B Cells
Kyoko Hayakawa, Masanao Asano, Susan A. Shinton, Ming Gui, David Allman, Colin L. Stewart, Jack Silver and Richard R. Hardy
New Series, Vol. 285, No. 5424 (Jul. 2, 1999), pp. 113-116
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/2898269
Page Count: 4
You can always find the topics here!Topics: B lymphocytes, Mice, Hybridomas, Thymocytes, T lymphocytes, Cell lines, Autoantigens, Autoantibodies, Neonates, Antigens
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Lymphocyte development is critically influenced by self-antigens. T cells are subject to both positive and negative selection, depending on their degree of self-reactivity. Although B cells are subject to negative selection, it has been difficult to test whether self-antigen plays any positive role in B cell development. A murine model system of naturally generated autoreactive B cells with a germ line gene-encoded specificity for the Thy-1 (CD90) glycoprotein was developed, in which the presence of self-antigen promotes B cell accumulation and serum autoantibody secretion. Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity.
Science © 1999 American Association for the Advancement of Science