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Different Trajectories of Parallel Evolution During Viral Adaptation
H. A. Wichman, M. R. Badgett, L. A. Scott, C. M. Boulianne and J. J. Bull
New Series, Vol. 285, No. 5426 (Jul. 16, 1999), pp. 422-424
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/2898852
Page Count: 3
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The molecular basis of adaptation is a major focus of evolutionary biology, yet the dynamic process of adaptation has been explored only piecemeal. Experimental evolution of two bacteriophage lines under strong selection led to over a dozen nucleotide changes genomewide in each replicate. At least 96 percent of the amino acid substitutions appeared to be adaptive, and half the changes in one line also occurred in the other. However, the order of these changes differed between replicates, and parallel substitutions did not reflect the changes with the largest beneficial effects or indicate a common trajectory of adaptation.
Science © 1999 American Association for the Advancement of Science