You are not currently logged in.
Access JSTOR through your library or other institution:
Precisely Localized LTD in the Neocortex Revealed by Infrared-Guided Laser Stimulation
H.-U. Dodt, M. Eder, A. Frick and W. Zieglgänsberger
New Series, Vol. 286, No. 5437 (Oct. 1, 1999), pp. 110-113
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/2898902
Page Count: 4
You can always find the topics here!Topics: Long term depression, Neurons, Tetanus, Lasers, Glutamate receptors, Electrical stimulation, Dendrites, Ultraviolet lasers, Neuroscience, Receptors
Were these topics helpful?See something inaccurate? Let us know!
Select the topics that are inaccurate.
Preview not available
In a direct approach to elucidate the origin of long-term depression (LTD), glutamate was applied onto dendrites of neurons in rat neocortical slices. An infrared-guided laser stimulation was used to release glutamate from caged glutamate in the focal spot of an ultraviolet laser. A burst of light flashes caused an LTD-like depression of glutamate receptor responses, which was highly confined to the region of "tetanic" stimulation (<10 micrometers). A similar depression of glutamate receptor responses was observed during LTD of synaptic transmission. A spatially highly specific postsynaptic mechanism can account for the LTD induced by glutamate release.
Science © 1999 American Association for the Advancement of Science