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Relation Of Angiographically Defined Coronary Artery Disease To Plasma Lipoprotein Subfractions And Apolipoproteins
N. E. Miller, F. Hammett, S. Saltissi, S. Rao, H. Van Zeller, J. Coltart and B. Lewis
British Medical Journal (Clinical Research Edition)
Vol. 282, No. 6278 (May 30, 1981), pp. 1741-1744
Published by: BMJ
Stable URL: http://www.jstor.org/stable/29502167
Page Count: 4
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The relation of coronary artery disease to plasma lipoproteins was examined in 104 men aged 35-65 years undergoing coronary angiography for suspected myocardial ischaemia. A score reflecting the number, degree, and length of stenoses in seven major coronary arteries was assigned to each angiogram. Lipid concentrations in lipoprotein subfractions were measured after preparative ultracentrifugation; plasma apolipoprotein concentrations were measured by electroimmunoassay. Men with high coronary scores tended to have lower plasma high-density lipoprotein (HDL) cholesterol concentrations and higher low-density lipoprotein (density 1.019-1.063 g/ml) cholesterol concentrations than subjects of similar age with low coronary scores (p≈). The strongest relation, however, was with the cholesterol concentration in the HDL₂ subfraction (density 1.063-1.125 g/ml) of HDL, which averaged 44% lower in the severely affected patients (p <0.005). No associations were found between the coronary score and HDL₃ cholesterol, the cholesterol content of lipoproteins of density <1.019 g/ml, plasma triglyceride, or the concentrations of apolipoproteins AI, AII, and E. The high coronary scores associated with low HDL₂ concentrations reflected an increase in the number of both partial and complete stenoses distributed throughout the coronary tree. In contrast the sizes of the lesions and the proportion producing complete occlusion were unrelated to HDL₂.
British Medical Journal (Clinical Research Edition) © 1981 BMJ