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Journal Article

Causes Of Venous Ulceration: A New Hypothesis

P. D. Coleridge Smith, P. Thomas, J. H. Scurr and J. A. Dormandy
British Medical Journal (Clinical Research Edition)
Vol. 296, No. 6638 (Jun. 18, 1988), pp. 1726-1727
Published by: BMJ
Stable URL: http://www.jstor.org/stable/29531106
Page Count: 2
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Abstract

Previous hypotheses about the causes of venous ulceration are inconsistent with recently published data. In patients with chronic venous insufficiency the number of functioning capillary loops visible in the skin on microscopy fell after the legs had been dependent for 30 minutes. Another study had shown that leucocytes became trapped in the circulation in dependent legs. A new hypothesis linking these two findings proposes that the trapped while cells occlude the capillaries and results in ischaemia of the skin of the leg.

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