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Generation of Specific Cytotoxic T Cells with a Fragment of the Epstein-Barr Virus-Encoded p63/Latent Membrane Protein

David A. Thorley-Lawson and Ethan S. Israelsohn
Proceedings of the National Academy of Sciences of the United States of America
Vol. 84, No. 15 (Aug. 1, 1987), pp. 5384-5388
Stable URL: http://www.jstor.org/stable/30042
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Generation of Specific Cytotoxic T Cells with a Fragment of the Epstein-Barr Virus-Encoded p63/Latent Membrane Protein
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Abstract

Human B lymphocytes, transformed by the herpesvirus Epstein-Barr virus, are known to express a characteristic antigen(s) recognized by the cellular immune response. This structure has been termed lymphocyte-determined membrane antigen. Because of the significance of this structure in controlling Epstein-Barr virus infection in vivo, the molecular nature of lymphocyte-determined membrane antigen has been long sought. In this paper, we show that a sequence of 10 amino acids (residues 43-53) from the Epstein-Barr virus-encoded membrane protein p63/latent membrane protein can induce Epstein-Barr virus-specific cytotoxic T cells and, therefore, bears at least one of the lymphocyte-determined membrane antigenic determinants.

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