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Oogenesis Requires Germ Cell-Specific Transcriptional Regulators Sohlh1 and Lhx8

Stephanie A. Pangas, Youngsok Choi, Daniel J. Ballow, Yangu Zhao, Heiner Westphal, Martin M. Matzuk and Aleksandar Rajkovic
Proceedings of the National Academy of Sciences of the United States of America
Vol. 103, No. 21 (May 23, 2006), pp. 8090-8095
Stable URL: http://www.jstor.org/stable/30049179
Page Count: 6
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Abstract

Mammalian oogenesis requires oocyte-specific transcriptional regulators. The full complement of oocyte-specific transcription factors is unknown. Here, we describe the finding that Sohlh1, a spermatogenesis and oogenesis basic helix-loop-helix transcription factor in females, is preferentially expressed in oocytes and required for oogenesis. Sohlh1 disruption perturbs follicular formation in part by causing down-regulation of two genes that are known to disrupt folliculogenesis: newborn ovary homeobox gene (Nobox) and factor in the germ-line alpha (FigIa). In addition, we show that Lhx8 is downstream of Sohlh1 and critical in fertility. Thus, Sohlh1 and Lhx8 are two germ cell-specific, critical regulators of oogenesis.

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