Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Positive Selection Driving Diversification in Plant Secondary Metabolism

Markus Benderoth, Susanne Textor, Aaron J. Windsor, Thomas Mitchell-Olds, Jonathan Gershenzon and Juergen Kroymann
Proceedings of the National Academy of Sciences of the United States of America
Vol. 103, No. 24 (Jun. 13, 2006), pp. 9118-9123
Stable URL: http://www.jstor.org/stable/30051907
Page Count: 6
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Positive Selection Driving Diversification in Plant Secondary Metabolism
Preview not available

Abstract

In Arabidopsis thaliana and related plants, glucosinolates are a major component in the blend of secondary metabolites and contribute to resistance against herbivorous insects. Methylthioalkylmalate synthases (MAM) encoded at the MAM gene cluster control an early step in the biosynthesis of glucosinolates and, therefore, are central to the diversification of glucosinolate metabolism. We sequenced bacterial artificial chromosomes containing the MAM cluster from several Arabidopsis relatives, conducted enzyme assays with heterologously expressed MAM genes, and analyzed MAM nucleotide variation patterns. Our results show that gene duplication, neofunctionalization, and positive selection provide the mechanism for biochemical adaptation in plant defense. These processes occur repeatedly in the history of the MAM gene family, indicating their fundamental importance for the evolution of plant metabolic diversity both within and among species.

Page Thumbnails

  • Thumbnail: Page 
9118
    9118
  • Thumbnail: Page 
9119
    9119
  • Thumbnail: Page 
9120
    9120
  • Thumbnail: Page 
9121
    9121
  • Thumbnail: Page 
9122
    9122
  • Thumbnail: Page 
9123
    9123