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Virucidal Activity of H₂O₂-Generating Bacteria: Requirement for Peroxidase and a Halide

Seymour J. Klebanoff and Melvin E. Belding
The Journal of Infectious Diseases
Vol. 129, No. 3 (Mar., 1974), pp. 345-348
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30061681
Page Count: 4
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Virucidal Activity of H₂O₂-Generating Bacteria: Requirement for Peroxidase and a Halide
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Abstract

An antagonistic relationship between H₂O₂-generating bacteria (Streptococcus mitis, Lactobacillus acidophilus) and viruses (poliovirus) is described. The antagonism is dependent on a peroxidase (lactoperoxidase, myeloperoxidase) and a halide (iodide, chloride) for maximal activity. This system may be operative in certain biological fluids.

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