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Experimental Studies of the Pathogenesis of Infections Due to Pseudomonas aeruginosa: Description of a Burned Mouse Model

Donald D. Stieritz and Ian Alan Holder
The Journal of Infectious Diseases
Vol. 131, No. 6 (Jun., 1975), pp. 688-691
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30061750
Page Count: 4
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Experimental Studies of the Pathogenesis of Infections Due to Pseudomonas aeruginosa: Description of a Burned Mouse Model
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Abstract

An experimental burned mouse model is described that is clinically relevant to burn wound sepsis caused by Pseudomonas aeruginosa. Mice subjected to a nonlethal burn by flame were challenged with P. aeruginosa. The $LD_{50}$ after subcutaneous injection in the skin of the burn up to 24 hr after the burn was <10 organisms vs. 10⁶ organisms in normal animals. By three days after the burn, the value returned to and exceeded that of normal animals. This dramatic change in the $LD_{50}$ after the burn was not seen when mice were challenged with other organisms. Challenge with P. aeruginosa by different routes immediately after burning showed less dramatic decreases in the $LD_{50}$. Enumeration of infecting organisms in the skin of the burn and in major organs suggests the possibility of a toxic event.

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