The Opsonic Index and Vaccine Therapy of Pseudodiphtheric Otitis

Alice Hamilton
The Journal of Infectious Diseases
Vol. 4, No. 3 (Jun. 15, 1907), pp. 313-325
Published by: Oxford University Press
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Page Count: 13
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The Opsonic Index and Vaccine Therapy of Pseudodiphtheric Otitis


Cases of otitis media which have pseudodiphtheria bacilli as the predominating organism in the pus from the ear have usually a low opsonic index for this bacillus. In certain cases in which repeated examinations are made the index is found to cover a wide range, and the changes in the index often correspond to changes in the clinical symptoms. By injections of dead cultures of the homologous strain the patient's opsonin to that strain can be increased. No ill effect follows such injections and an apparent improvement has resulted in several cases. The opsonin in the blood of these patients is specific for the variety of pseudodiphtheria bacilli to which the patient's strain belongs. This constitutes a strong proof that the pseudodiphtheria bacillus plays an etiologic role in such cases.>

Notes and References

This item contains 1 reference.

  • 1
    Hamilton and Horton, Jour. Infect. Dis., 1906, 3, p. 128.