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On the Protection Afforded to Red Cells against Hemolysis by Eosin

Carl L. A. Schmidt and G. F. Norman
The Journal of Infectious Diseases
Vol. 27, No. 1 (Jul., 1920), pp. 40-45
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30080700
Page Count: 5
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Abstract

The object of the investigation was to determine the cause of the inability of gelatin to red cells against the photodynamic asction of eosin. Since gelatin lacks certain amino acids that are contained in the protein molecules which afford protection, experiments were carried out to determine the protection afforded by individual amino acids. It was found that tyrosin and trytophan offer marked protection, while pheylalanin, glycocoll, leucin, asprtic acid, alanin, cystin and glutamic acid are ineffective. Certain other substances containing a hydroxyphenyl group in the molecule also protect re blood cells againts hemolysis by eosin.Since aaction by light cannot take place without absortion, it is possible that the protection afforded to red cells by certain substances againts the photodynamic effect of eosin is due to the absorption of the active rays by the protective substance.

Notes and References

This item contains 8 references.

[Footnotes]
  • 1
    This reference contains 2 citations:
    • Ztschr. f. Biol., 1900, 39, p. 524
    • 1903, 44, p. 16
  • 2
    München. med. Wchnschr., 1900, 47, p. 5.
  • 3
    This reference contains 9 citations:
    • Ibid., 1904, 51, p. 737
    • Deut. Arch. klin. Med., 1904, 80, p. 427
    • 1905, 85, p. 386
    • 1906, 86, p. 468 and p. 479
    • Kudo and Jodlbauer: Biochem. Ztschr., 1908, 13, p. 24
    • Harz- becker and Jodlbauer: ibid., 12, p. 306
    • Neuberg: ibid., 13, p. 305
    • von Tappeiner: Ergeb. der Physiol., 1909, 8, p. 698
    • Neuberg and Galambos: Biochem. Ztschr., 1914, 61, p. 315
  • 4
    Biochem. Ztschr., 1906, 1, p. 425.
  • 5
    J. Med. Research, 1918, 38, p. 293.
  • 6
    This reference contains 2 citations:
    • Fischer, Levene and Aders: Ztschr. physiol. Chem., 1902, 35, p. 70
    • Levene and Beatty: Ztschr. physiol. Chem., 1906, 49, p. 252
  • 7
    This reference contains 3 citations:
    • Harris and Hoyt: Science, 1917, 46, p. 318
    • University of Cal. Pub. Path., 1919, 2, p. 245
    • Hill and Schmidt: J. Infect. Dis., 1919, 25, p. 335
  • 9
    Chem. Engineer, 1919, 27, p. 141.