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Formation of Antibody in the Newborn Mouse: Study of T-Cell-Independent Antibody Response

D. E. Mosier, N. M. Zaldivar, E. Goldings, J. Mond, I. Scher and W. E. Paul
The Journal of Infectious Diseases
Vol. 136, Supplement. Current Status and Prospects for Improved and New Bacterial Vaccines (Aug., 1977), pp. s14-s19
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30081778
Page Count: 6
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Formation of Antibody in the Newborn Mouse: Study of T-Cell-Independent Antibody Response
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Abstract

The ontogeny of immune responsiveness, as assayed by antibody formation in vitro, of mouse spleen lymphocytes to thymus-independent antigens is reviewed. Responsiveness to trinitrophenyl (TNP)-lipopolysaccharide and TNP-Brucella abortus appear soon after birth and one to two weeks before TNP-Ficoll or capsular polysaccharide of Streptococcus pneumoniae (SSS-III) elicits significant antibody formation. This hierarchy of responsiveness to antigens is also apparent in the CBA/N mutant mouse strain, which has a bone marrow-derived (B-) cell maturation arrest and fails to respond to either TNP-Ficoll or SSS-III. These findings are interpreted to suggest sequential maturation of different populations or lines of B-lymphocytes, each of which can respond to a defined class of thymus-independent antigens. The implication for vaccine use in humans is that a late-appearing subclass of B-cells may be required for adequate immune responses to polysaccharide antigens.

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