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A Study of Antigenic Properties of Bacteriophage

Emil Weiss and Lloyd Arnold
The Journal of Infectious Diseases
Vol. 34, No. 3 (Mar., 1924), pp. 317-327
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30083161
Page Count: 11
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A Study of Antigenic Properties of Bacteriophage
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Abstract

Bacteriophage increases the phagocytic power of leukocytes and is in direct proportion to the potency of the bacteriophage. Antilysins are the antibodies of the bacteriophage, and their action is specific. Antibacteriophage serum prepared by d'Herelle's method gives a higher agglutination titer than when prepared by the bottom layer agar method. When the agglutinins are absorbed from antibacteriophage serum, this serum no longer gives precipitation or complement fixation with the bacteriophage and does not exert any influence on the phagocytic activity of leukocytes. The antilytic properties of such serums are not decreased. A nonspecific precipitation, complement-fixation or increase in phagocytic power could not be obtained.The bacteriophage reacts antigenically like a ferment.

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