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Antigenic Analysis of Strains of Bacillus Typhosus

Leon C. Havens
The Journal of Infectious Diseases
Vol. 43, No. 4 (Oct., 1928), pp. 335-344
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30083551
Page Count: 10
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Antigenic Analysis of Strains of Bacillus Typhosus
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Abstract

The antigenic identity of strains of B.typhosus has been studied by agglutinin absorption, complement fixation, and bactericidal activity. The greatest differences between strains were obtained by agglutinin absorption with fractional doses. Complement fixation and bactericidal tests indicated only minor differences between the strains tested. Agglutinin absorption is probably the most sensitive method of bringing out differences in antigenic composition. The results indicate that the method is more delicate than practical uses demand. The suitability of a particular culture for the Widal test or for vaccine cannot be definitely determined by means of these experiments, but they indicate that complement fixation and bactericidal tests conform most closely to the empirical evidence gained from practical application in the field.

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