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Studies on Botulinus Toxin: 3. Acid Precipitation of Botulinus Toxin [with Discussion]

P. Tessmer Snipe and H. Sommer
The Journal of Infectious Diseases
Vol. 43, No. 2 (Aug., 1928), pp. 152-160
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30083772
Page Count: 9
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Abstract

The potency of impure or of purified botulinus toxin cannot be increased by acidification. The data presented in the literature can be explained on a different basis. By acidification of botulinum (type A) culture fluids toxic substances were isolated representing 0.5 to 4% of the total potency and having a toxicity of 5 x 10⁻⁷ to 5 x 10⁻⁸ gm. per MLD. By dialysis of acidified culture fluids 8 to 28% of the original number of MLD can be recovered with a toxicity of 3 x 10⁻⁸-1 x 10⁻⁸ gm. per MLD. The preparations give the biuret reaction, contain a small amount of phosphorus and exhibit slight enzymatic actions.

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