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Herpes Encephalitis in Monkeys of the Genus Cebus: With Observations on the Green Streptococcus

Earl B. McKinley and Margaret Douglass
The Journal of Infectious Diseases
Vol. 47, No. 6 (Dec., 1930), pp. 511-522
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30084671
Page Count: 11
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Herpes Encephalitis in Monkeys of the Genus Cebus: With Observations on the Green Streptococcus
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Abstract

Herpetic encephalitis has been produced in five of nine monkeys of the genus Cebus. The disease in its acute and subcute form closely resembles human encephalitis. The pathologic lesions are also similar to those of the human malady, except for the presence of intranuclear herpetic inclusion bodies in the ganglion cells of the cortex. The disease kills Cebus monkeys in from six to eleven days. Secondary invading streptococci were demonstrated in the brain of one monkey. Healthy monkeys receiving an eniulsion of the brain of this monkey did not show any streptococci, either on cultivation of the brain or on inoculation of it in rabbits. Our studies indicate that the green streptococcus is not related to the virus infection in question, but that this microbe may, in occasional animals under optimum conditions, invade the central nervous system after the "soil" has been previously prepared by the virus. We therefore see no reason for attaching an etiologic relationship to the green streptococcus in such a disease as encephalitis. Difficulty has been met with in attempting to transmit herpes encephalitis from monkey to monkey. This may be due to the chance selection of refractory animals, or in some manner a neutralization of the herpes virus may occur in the brains of some monkeys.

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