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Investigation of Certain Synthetic Glucosides for Antigenic Properties

Arnold G. Wedum
The Journal of Infectious Diseases
Vol. 52, No. 2 (Mar. - Apr., 1933), pp. 203-208
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30085091
Page Count: 6
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Investigation of Certain Synthetic Glucosides for Antigenic Properties
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Abstract

Twenty-two glucosides of known composition were synthesized. These represented a wide range of structural formulae, solubilities, and, in the condition in which they were used, a range of physical state from simple solutions through suspensoids and suspensions. The dispersing mediums were water; saline solution; glycol; 10 per cent and 20 per cent alcohol; 0.5 per cent gelatin; 0.5 per cent gelatin, 95 parts, plus acetone, 4 parts. These glucosides were tested for antigenic properties by injecting them into guinea-pigs for the production of precipitins, agglutinins and anaphylactins. In no instance were precipitins or agglutinins demonstrated or evidence of anaphylaxis. Pseudoprecipitation and pseudo-agglutination sometimes occurred.

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