You are not currently logged in.
Access JSTOR through your library or other institution:
Salivary Secretory Leukocyte Protease Inhibitor Is Associated with Reduced Transmission of Human Immunodeficiency Virus Type 1 through Breast Milk
Carey Farquhar, Thomas C. VanCott, Dorothy A. Mbori-Ngacha, Lena Horani, Rose K. Bosire, Joan K. Kreiss, Barbra A. Richardson and Grace C. John-Stewart
The Journal of Infectious Diseases
Vol. 186, No. 8 (Oct. 15, 2002), pp. 1173-1176
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30085220
Page Count: 4
You can always find the topics here!Topics: HIV 1, Infants, Breast milk, Saliva, Infections, Disease transmission, Leukocytes, Protease inhibitors, Disease risk, HIV
Were these topics helpful?See something inaccurate? Let us know!
Select the topics that are inaccurate.
Preview not available
Secretory leukocyte protease inhibitor (SLPI), a protein found in saliva, breast milk, and genital secretions, is capable of inhibiting human immunodeficiency virus (HIV) type 1 in vitro. The aim of this study was to determine whether SLPI in infant saliva provides protection against mother-to-child HIV-1 transmission. In total, 602 saliva specimens were collected from 188 infants at birth and at ages 1, 3, and 6 months. Infants' median salivary SLPI concentrations were higher at birth than at 6 months (341 vs. 219 ng/mL; P = .001). There was no association between SLPI concentration and HIV-1 transmission overall. However, among 122 breast-fed infants who were HIV-1 uninfected at 1 month, higher salivary SLPI levels were associated with a decreased risk of HIV-1 transmission through breast milk (hazard ratio, 0.5; 95% confidence interval, 0.3-0.9; P = .03). These results suggest that SLPI plays an important role in reducing HIV-1 transmission through breast milk.
The Journal of Infectious Diseases © 2002 Oxford University Press