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Human Herpesvirus 8 Infection within Families in Rural Tanzania

Sam M. Mbulaiteye, Ruth M. Pfeiffer, Denise Whitby, Glen R. Brubaker, John Shao and Robert J. Biggar
The Journal of Infectious Diseases
Vol. 187, No. 11 (Jun. 1, 2003), pp. 1780-1785
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30085667
Page Count: 6
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Human Herpesvirus 8 Infection within Families in Rural Tanzania
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Abstract

Human herpesvirus 8 (HHV-8) infection is common in Africa. We examined the distribution of HHV-8 within families in rural Tanzania to determine routes of spread. HHV-8 infection was assessed by measuring antibody reactivity with a K8.1 (lytic-phase antigen) immunoassay. The prevalence increased from 3.7% (1/27) among infants to 58.1% (36/62) among children aged 3-4 years and 89.0% (65/73) among adults aged ⩾45 years. Women with HHV-8-seropositive husbands had a 7-fold risk for infection (odds ratio [OR], 6.9; 95% confidence interval [CI], 1.9-25.3). HHV-8 seropositivity in children was associated with having at least 1 seropositive first-degree relative (OR, 14.7; 95% CI, 5.9-43.1), a seropositive mother (OR, 7.4; 95% CI, 3.2-16.8), a seropositive father (OR, 4.8; 95% CI, 2.3-10.1), or a seropositive next-older sibling (OR, 4.2; 95% CI, 1.9-9.4). Our data are consistent with the occurrence of HHV-8 transmission within families, from mothers and other relatives to children via nonsexual routes and between spouses via sexual routes.

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