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Classification of Hepatitis B Virus Genotype B into 2 Major Types Based on Characterization of a Novel Subgenotype in Arctic Indigenous Populations

Tomoyuki Sakamoto, Yasuhito Tanaka, Josephine Simonetti, Carla Osiowy, Malene L. Børresen, Anders Koch, Fuat Kurbanov, Masaya Sugiyama, Gerald Y. Minuk, Brian J. McMahon, Takashi Joh and Masashi Mizokami
The Journal of Infectious Diseases
Vol. 196, No. 10 (Nov. 15, 2007), pp. 1487-1492
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30086731
Page Count: 6
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Classification of Hepatitis B Virus Genotype B into 2 Major Types Based on Characterization of a Novel Subgenotype in Arctic Indigenous Populations
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Abstract

Hepatitis B virus genotype B (HBV/B) has been classified into 5 subgenotypes. Except for Bj/B1 in Japan, the subgenotypes (Ba/B2-B5) have undergone recombination with HBV/C in the core promoter/precore/core genomic region. Phylogenetic analyses of complete sequences show that the Arctic strains belong to a novel subgenotype (HBV/B6) without the recombination, analogous to what is seen with Bj/B1. Comparison of 50 HBV/B6 carriers from the Arctic versus 50 Bj and 50 Ba ageand sex-matched carriers from Asia revealed that clinical characteristics of HBV/B6 carriers were similar to those of Bj/B1 carriers in Japan. The results suggest that HBV/B may be classified into nonrecombinant (Bj/B1 and B6) and recombinant (Ba/B2-B5) types.

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