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Hepatitis B Virus Genotypes in Alaska Native People with Hepatocellular Carcinoma: Preponderance of Genotype F
Stephen E. Livingston, Josephine P. Simonetti, Brian J. McMahon, Lisa R. Bulkow, Kathy J. Hurlburt, Chriss E. Homan, Mary M. Snowball, Henry H. Cagle, James L. Williams and Vladimir P. Chulanov
The Journal of Infectious Diseases
Vol. 195, No. 1 (Jan. 1, 2007), pp. 5-11
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30087445
Page Count: 7
You can always find the topics here!Topics: Genotypes, Hepatocellular carcinoma, Hepatitis B virus, Alaska Natives, Infections, Genetic mutation, Polymerase chain reaction, Diseases, Promoter regions, Liver diseases
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Background. The development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection has been associated with specific HBV genotypes and the presence of specific mutations. Methods. From a cohort of Alaska Native people with chronic HBV infection, we genotyped 47 patients with HCC and 1129 patients without HCC, and we tested patients with HCC and control patients for mutations in the basal core promoter and precore regions. Results. Genotype F was found in 68% of patients with HCC, versus 18% of those without HCC (P>.001). For patients with genotype F, the median age at diagnosis of HCC was lower than that for patients with other genotypes (22.5 vs. 60 years, respectively; P = .002). Overall, there were no significant differences in the number of basal core promoter and precore region mutations between patients with HCC and control patients. Conclusions. We found a significant association between genotype F and the development of HCC among Alaska Native people with chronic HBV infection but no significant association between HCC and basal core promoter or precore mutations in genotype F.
The Journal of Infectious Diseases © 2007 Oxford University Press