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Protective Immunity to Cytomegalovirus (CMV) Retinitis in AIDS Is Associated with CMV-Specific T Cells That Express Interferon-γ and Interleukin-2 and Have a CD8⁺ Cell Early Maturational Phenotype

Elizabeth Sinclair, Qi Xuan Tan, Margaret Sharp, Valerie Girling, Chungkee Poon, Mark Van Natta, Douglas A. Jabs, Margaret Inokuma, Holden T. Maecker, Barry Bredt, Mark A. Jacobson and Studies of Ocular Complications of AIDS Research Group
The Journal of Infectious Diseases
Vol. 194, No. 11 (Dec. 1, 2006), pp. 1537-1546
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30087526
Page Count: 10
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Protective Immunity to Cytomegalovirus (CMV) Retinitis in AIDS Is Associated with CMV-Specific T Cells That Express Interferon-γ and Interleukin-2 and Have a CD8⁺ Cell Early Maturational Phenotype
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Abstract

To determine potential correlates of immune recovery from AIDS-related cytomegalovirus retinitis (CMVR), multiparameter flow cytometry was used to characterize CMV-specific T cells from subjects with CMVR. Individuals with active retinitis were compared with those who had been clinically immunorestored by antiretroviral therapy and had ≥2 years of ophthalmologic follow-up without anti-CMV therapy or retinitis reactivation or progression. In comparison with patients with active retinitis, immunorestored patients had higher circulating CD4⁺ and CD8⁺ T cells expressing interleukin-2 and interferon-γ in response to combined CMV pp65 and IE1 peptide pool stimulation. CD4⁺ T cell responses were predominantly to pp65, whereas CD8⁺ T cell responses were predominantly to IE. Immunorestored patients, compared with patients with active retinitis, had increased levels of circulating CMV-specific CD8⁺ T cells with "early" (CD27⁺CD28⁺CD45RA⁺, CD27⁺CD28⁺CD45RA⁻) and "intermediate" (CD27⁻CD28⁺CD45RA⁻) phenotypes. Recovery from AIDS-related CMVR after the initiation of antiretroviral therapy may be mediated by CMV-specific CD4⁺ and CD8⁺ T cells capable of promoting antigen-specific CD8⁺ T cell proliferation.

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