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Brucella Infection in White Mice

Charlotte H. Singer-Brooks
The Journal of Infectious Diseases
Vol. 60, No. 3 (May - Jun., 1937), pp. 265-278
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30089205
Page Count: 14
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Brucella Infection in White Mice
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Abstract

Normal white mice succumb quickly to large doses of living Brucella organisms (300,000,000 to 400,000,000). Normal mice subjected to smaller dosage (30,000,000 to 300,000) organisms manifest no symptoms of infection but develop necrotic areas in the liver, and enlargement of the spleen. Infections of 100,000 to 1,000 organisms do not produce gross anatomical change, but the organisms are harbored in various tissues for long periods of time. Protection against fatal infection was conferred by immunization with heat killed vaccine in 95% of the animals treated. Pregnancies in immunized mice subjected to lethal infection are not terminated by abortions. The young survive and develop into healthy adults. Immunized mice subjected to small infections do not manifest any appreciable increase in ability to free their tissues of Brucella organisms as compared with control mice.

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