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Experimental Eosinophilia with Keratin from Ascaris suum and Other Sources

Dan H. Campbell
The Journal of Infectious Diseases
Vol. 71, No. 3 (Nov. - Dec., 1942), pp. 270-276
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30089627
Page Count: 7
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Experimental Eosinophilia with Keratin from Ascaris suum and Other Sources
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Abstract

The foregoing experiments demonstrate the eosinophilotactic properties of keratin fractions from several helminths, but fail to substantiate previous reports that other types of proteins or lipids show this property. This property is not unique for helminth keratin, but is also shown by keratins from a variety of sources as well as for heat coagulated ovalbumin. These substances are not eosinophilotactic per se but produce an eosinophilia following a single injection because they remain in the body after antibodies are formed, giving rise to hypersensitive responses. The activity of these substances in relation to (1) insolubility, (2) antigenicity and (3) the presence of - SH groups are discussed.

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