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The Response of Different Types and Strains of Pneumococcus to Sulfapyridine
L. H. Schmidt, Carolyn Hilles, H. A. Dettwiler and Effie Starks
The Journal of Infectious Diseases
Vol. 67, No. 3 (Nov. - Dec., 1940), pp. 232-242
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30092213
Page Count: 11
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Sulfapyridine was uniformly more effective against experimental infections with type I pneumococcus than against infections with type III. Infections with certain type II strains responded as did type I pneumococcus, whereas infections with other strains responded as did type III. In vitro experiments showed that these type and strain variations were not related to differences in the bacteriostatic action of sulfapyridine. Nor were they due to retention of occasional organisms in isolated organs. It has been suggested that these differences in type and strain response were related to differences in antigenicity-the effectiveness of therapy being directly proportional to the capacity of the organisms to stimulate antibody formation.
The Journal of Infectious Diseases © 1940 Oxford University Press