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The Ascorbic Acid Concentration of Inflammatory Lesions of the Skin

Calvin C. Torrance
The Journal of Infectious Diseases
Vol. 67, No. 1 (Jul. - Aug., 1940), pp. 53-58
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30092252
Page Count: 6
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The Ascorbic Acid Concentration of Inflammatory Lesions of the Skin
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Abstract

The ascorbic acid concentration of the dermal lesions induced in guinea pigs, rabbits, and rats by diphtheria toxin was found to be significantly lower than that of the corresponding uninjected areas on the opposite side of the body. Similar changes occurred in the vitamin C concentration of the dermal lesions induced by heat. No such changes were found following the injection of toxin into the skin of rats in which the dose given induced no inflammatory reaction. It appears from these experiments that the observed changes in the ascorbic-acid concentration are associated with the development of the inflammatory lesion and are not directly influenced by the presence of the toxin. It is suggested that the total amount of ascorbic acid in a local lesion may affect capillary permeability and thus the edema.

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