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The Effect of X Irradiation on Infections with Plasmodium berghei in the White Mouse

Ira Singer
The Journal of Infectious Diseases
Vol. 92, No. 1 (Jan. - Feb., 1953), pp. 97-104
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30092305
Page Count: 8
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The Effect of X Irradiation on Infections with Plasmodium berghei in the White Mouse
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Abstract

Mice were irradiated 24 hours prior to, immediately before, 1 day, 3 days, 5 days or 7 days after infection with Plasmodium berghei. Alternate groups of animals were subjected to either 550r or 250r total body irradiation. Five hundred and fifty r administered up to the 3rd day of infection induced a low parasitemia in infected mice, which reached its peak on approximately the the 5th day of infection, and subsequently dropped to below 10 parasites per 10,000 erythrocytes until the death of the animals. When 550r were administered on the 5th or 7th day after infection, the parasitemia never dropped below 40 parasites per 10,000 red blood cells and before the infection was terminated by death rose to between 2000 and 6000 parasites per 10,000 erythrocytes. Two hundred and fifty r adminis- before infection resulted in a course of infection similar to that of the controls, but maintained at a lower level. Two hundred and fifty r administered after infection led to a primary rise in the numbers of parasites 24 hours after irradiation and a subsequent course of infection lower than that of the infected controls. These results are tereddiscussed in relation to the parasite's preference for immature mouse erythrocytes and the inability of the host to supply these cells due to X-ray damage.

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