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A Polysaccharide Fraction from Cysticercus crassicollis and Its Rôle in Immunity

Dan H. Campbell
The Journal of Infectious Diseases
Vol. 65, No. 1 (Jul. - Aug., 1939), pp. 12-15
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30093852
Page Count: 4
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A Polysaccharide Fraction from Cysticercus crassicollis and Its Rôle in Immunity
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Abstract

Although immunoserologic antibodies against the polysaccharide fraction from C. crassicollis can be induced in rabbits either by injection of whole parasite material or by the polysaccharide itself, such antibodies apparently play no rôle in protection against infection. This was shown by (1) the failure to increase the resistance of rats by injection of the polysaccharide, (2) the failure to reduce the protective power of rabbit anticysticercus serum by absorption of the antipolysaccharide antibodies, and (3) the failure to demonstrate any protective power for the antipolysaccharide antibodies induced by injections of the polysaccharide in rabbits. In those cases where polysaccharides of bacteria play an important rôle in immunity reactions, the polysaccharide is exposed to the action of antibody and the subsequent destruction of such material reduces the resistance of the organism to the defensive activities of the host. However, in the case of Cysticercus, it is likely that the polysaccharide of the intact organism is not exposed to the action of antipolysaccharide antibodies and perhaps also that such material is not of vital importance to the parasite.

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